{"id":2132,"date":"2020-11-25T17:44:15","date_gmt":"2020-11-26T00:44:15","guid":{"rendered":"http:\/\/patandstacy.com\/blog\/?p=2132"},"modified":"2020-11-30T09:26:34","modified_gmt":"2020-11-30T16:26:34","slug":"azd-1222-pandemic-pioneering","status":"publish","type":"post","link":"https:\/\/patandstacy.com\/blog\/2020\/11\/25\/azd-1222-pandemic-pioneering\/","title":{"rendered":"AZD-1222: Pandemic Pioneering"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4794-1024x768.jpg\" alt=\"I am participating in the AstraZeneca COVID-19 Vaccine Clinical Trial. \" class=\"wp-image-2134\" width=\"584\" height=\"438\" srcset=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4794-1024x768.jpg 1024w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4794-300x225.jpg 300w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4794-768x576.jpg 768w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4794-1536x1152.jpg 1536w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4794-2048x1536.jpg 2048w\" sizes=\"auto, (max-width: 584px) 100vw, 584px\" \/><figcaption>Behold, the evidence of injection. I don&#8217;t know if it was <strong>THE<\/strong> injection or <em>an<\/em> injection, and won&#8217;t for another two years, but I have my suspicions&#8230;<\/figcaption><\/figure>\n\n\n\n<p>My head hurts. <\/p>\n\n\n\n<p>Is it allergies? Is it stress from the white-knuckle madness of Los Angeles traffic? Is it the two glasses of red wine I drank last night? <\/p>\n\n\n\n<p>Is it a cellular response to a self-inflicted invader? The harbinger of  Immunity.<\/p>\n\n\n\n<p>I won&#8217;t know for certain for two years. <\/p>\n\n\n\n<p>Yesterday, I enrolled in the AstraZeneca COVID-19 Vaccine Phase III Clinical Trials (<a href=\"https:\/\/astrazenecagrouptrials.pharmacm.com\/ST\/Submission\/View?id=26198\">AZD-1222),<\/a> volunteering my blood and guts to fight the greatest threat to humanity since the Cold War: SARS-CoV-2, which has infected 60 million people worldwide since December 2019, killing 1.4 million of them. <\/p>\n\n\n\n<p>As opposed to the <a href=\"https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/different-vaccines\/mrna.html\" data-type=\"URL\" data-id=\"https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/different-vaccines\/mrna.html\">sexier mRNA-based vaccines developed by Pfizer \/ BioNTech and Moderna<\/a>, the AstraZeneca vaccine is vector-based: It uses a common cold-type virus as a Trojan horse to introduce an altered gene for the coronavirus protein into my cells in hopes of training my immune system to recognize and destroy COVID-19. <\/p>\n\n\n\n<p>Or not. <\/p>\n\n\n\n<p>It&#8217;s a double-blind trial, so I will not know if I got <strong>THE<\/strong> shot or merely <em>a<\/em> shot for two years. Until then, I will wallow in hypochondria &#8211; or at least for the next 48 hours. The clinical trial nurses advised me to watch out for certain side effects during the first two days:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache <\/li><li>Fatigue<\/li><li>Fever or chills<\/li><li>Muscle or body aches<\/li><li>Diarrhea or nausea<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4786-1024x1024.jpg\" alt=\"Test kit\" class=\"wp-image-2138\" srcset=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4786-1024x1024.jpg 1024w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4786-300x300.jpg 300w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4786-150x150.jpg 150w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4786-768x768.jpg 768w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4786.jpg 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>I gave blood and urine samples, learned I wasn&#8217;t pregnant (duh), and had the back of my skull scratched with a swab. Yay me!<\/figcaption><\/figure>\n\n\n\n<p>I will spare you the gurgling details, but my stomach is upset.<\/p>\n\n\n\n<p>Is it a side effect of <strong>THE<\/strong> shot? Or merely a symptom of yesterday&#8217;s truck stop feast of Lays Limon-flavored chips, Oberto peppered beef jerky, orange-flavored Gatorade Zero, and Australian Licorice (assorted fruit flavors)? Don&#8217;t judge. <\/p>\n\n\n\n<p>Enrolling in the trial was a breeze: <a href=\"https:\/\/astrazenecagrouptrials.pharmacm.com\/ST\/Submission\/View?id=26198\" data-type=\"URL\" data-id=\"https:\/\/astrazenecagrouptrials.pharmacm.com\/ST\/Submission\/View?id=26198\">Sign up online and wait for a call<\/a>. <\/p>\n\n\n\n<p>AstraZeneca is still recruiting volunteers and especially needs African-American, Latinx, and Native American participants. It&#8217;s important because people of color are historically underrepresented in clinical trials &#8211; in part because these populations have been victimized by unethical practices, see <a href=\"https:\/\/www.hopkinsmedicine.org\/henriettalacks\/\" data-type=\"URL\" data-id=\"https:\/\/www.hopkinsmedicine.org\/henriettalacks\/\">Henrietta Lacks<\/a>, <a href=\"https:\/\/www.cdc.gov\/tuskegee\/index.html\" data-type=\"URL\" data-id=\"https:\/\/www.cdc.gov\/tuskegee\/index.html\">Tuskegee Health Benefit Program<\/a>, et al, and also because lazy researchers didn&#8217;t actively recruit and study populations that reflect the diversity of our nation. Most critically, African-Americans, Latinx and Native Americans have been disproportionately affected by COVID-19 &#8211; and are more likely to die from it &#8211; so volunteering for the vaccine trial can help scientists identify differences that may not be apparent if a bunch of white people like me show up.<\/p>\n\n\n\n<figure class=\"wp-block-video\"><video controls src=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4785.MOV.mp4\"><\/video><figcaption>Apparently if they don&#8217;t spark tears, they aren&#8217;t doing the COVID test right. Ouch!<\/figcaption><\/figure>\n\n\n\n<p>My left shoulder hurts. My knees bend audibly. Intermittent pain steals through my joints: Are these the aches they warned me about? The physiological echo of an existential battle inside my cells? <\/p>\n\n\n\n<p>Or is it just a by-product of being a 48-year-old woman who has crashed her mountain bike on more than one occasion?<\/p>\n\n\n\n<p>My day started at the appointed 8 AM in a nondescript doctor&#8217;s office in Phoenix. They reviewed the 26-page consent form, which I had read prior to my visit and which detailed my rights as a volunteer: I can withdraw at any time, no questions asked. If I contract COVID, they will funnel me into a different study and manage my care. I will have two shots spaced 29 days apart of either the real deal or a placebo, and 66 percent of volunteers receive the real deal. I will have seven visits to this doctor&#8217;s office over the next two years and several phone calls as they monitor my progress.<\/p>\n\n\n\n<p>Sign here and here and here. Initial there and there and there.<\/p>\n\n\n\n<p>Then the delightful Matt did a blood draw, from which they&#8217;ll extract my genetic material for study.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4787-768x1024.jpg\" alt=\"\" class=\"wp-image-2140\" width=\"384\" height=\"512\" srcset=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4787-768x1024.jpg 768w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4787-225x300.jpg 225w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4787-1152x1536.jpg 1152w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4787-1536x2048.jpg 1536w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4787-scaled.jpg 1920w\" sizes=\"auto, (max-width: 384px) 100vw, 384px\" \/><figcaption>Nice stick, Matt. I told you I was a bleeder.<\/figcaption><\/figure>\n\n\n\n<p>Then I got a physical exam from the doctor and walked down the hall to meet my destiny.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4788-1-1024x1024.jpg\" alt=\"\" class=\"wp-image-2141\" srcset=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4788-1-1024x1024.jpg 1024w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4788-1-300x300.jpg 300w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4788-1-150x150.jpg 150w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4788-1-768x768.jpg 768w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4788-1.jpg 1080w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>Somehow, it seems like Nurse Ratched should be manning this room, but actually, the nurses were AWESOME. An easy stick&#8230; but was it the real stick?<\/figcaption><\/figure>\n\n\n\n<p>The nurses walked me through the consents again and reminded me of the aforementioned symptoms to monitor for the next 48 hours. I went to bed at 8:30 last night and slept soundly until the splitting headache awakened me at 4:27. I got winded climbing the stairs then fell asleep in the hammock this afternoon. Are these the telltale signs of vaccine-induced fatigue? Or just symptoms of middle age?<\/p>\n\n\n\n<p>I won&#8217;t know for another two years, but even if I learn that I got a shoulder-full of saline solution, at least I&#8217;ll know I did my part.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"1024\" src=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4793-768x1024.jpg\" alt=\"\" class=\"wp-image-2143\" srcset=\"https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4793-768x1024.jpg 768w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4793-225x300.jpg 225w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4793-1152x1536.jpg 1152w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4793-1536x2048.jpg 1536w, https:\/\/patandstacy.com\/blog\/wp-content\/uploads\/2020\/11\/IMG_4793-scaled.jpg 1920w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><figcaption>Ouch!<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>My head hurts. Is it allergies? Is it stress from the white-knuckle madness of Los Angeles traffic? Is it the two glasses of red wine I drank last night? Is it a cellular response to a self-inflicted invader? The harbinger of Immunity. I won&#8217;t know for certain for two years. Yesterday, I enrolled in the &hellip; <a href=\"https:\/\/patandstacy.com\/blog\/2020\/11\/25\/azd-1222-pandemic-pioneering\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">AZD-1222: Pandemic Pioneering<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-2132","post","type-post","status-publish","format-standard","hentry","category-adventure"],"_links":{"self":[{"href":"https:\/\/patandstacy.com\/blog\/wp-json\/wp\/v2\/posts\/2132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/patandstacy.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/patandstacy.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/patandstacy.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/patandstacy.com\/blog\/wp-json\/wp\/v2\/comments?post=2132"}],"version-history":[{"count":6,"href":"https:\/\/patandstacy.com\/blog\/wp-json\/wp\/v2\/posts\/2132\/revisions"}],"predecessor-version":[{"id":2145,"href":"https:\/\/patandstacy.com\/blog\/wp-json\/wp\/v2\/posts\/2132\/revisions\/2145"}],"wp:attachment":[{"href":"https:\/\/patandstacy.com\/blog\/wp-json\/wp\/v2\/media?parent=2132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/patandstacy.com\/blog\/wp-json\/wp\/v2\/categories?post=2132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/patandstacy.com\/blog\/wp-json\/wp\/v2\/tags?post=2132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}